Design,Synthesis, and Biological Evaluation of Novel 6H-Benzo[c]chromen-6-one Derivatives as Potential Phosphodiesterase II Inhibitors

Urolithins (hydroxylated 6H-benzo[c]chromen-6-ones) are the main bioavailable metabolites of ellagic acid (EA), which was shown to be a cognitive enhancer in the treatment of neurodegenerative diseases. As part of this research, a series of alkoxylated 6H-benzo[c]chromen-6-one derivatives were designed and synthesized. Furthermore, their biological activities were evaluated as potential PDE2 inhibitors, and the alkoxylated 6H-benzo[c]chromen-6-one derivative 1f was found to have the optimal inhibitory potential (IC₅₀: 3.67 ± 0.47 μM). It also exhibited comparable activity in comparison to that of BAY 60-7550 in vitro cell level studies.     

不同木质素磺酸钠对豆粕胶黏剂性能的影响

通过FTIR、元素分析、GPC对4种不同来源的木质素磺酸钠进行物理化学性质分析,并将其与水性聚酰胺协同改性豆粕胶黏剂(简称豆粕胶),利用测试接触角、剪切黏度和湿态胶合强度考察改性前后胶黏剂的浸润性、流变特性以及所得胶合板的胶合性能.红外谱图分析表明,在1065 cm–1附近出现了磺酸基或磺甲基中S==O的伸缩振动吸收峰,证明木质素经过磺化反应或磺甲基化反应得到木质素磺酸钠;木质素磺酸钠中磺酸基含量越高,经其改性的豆粕胶的零剪切黏度越低且在木材表面的润湿性越好;豆粕胶黏剂与杨木单板的接触角从未改性的95°降到改性后的61°;与水性聚酰胺协同改性后的豆粕胶制得胶合板的湿态胶合强度达到0.92 MPa,合格率为100％,满足国家Ⅱ类胶合板的标准要求(胶合强度≥0.70 MPa,合格率≥90％).     

生物质能源转化技术与应用(Ⅲ)——生物质热解液体燃料油制备和精制技术

生物质能源是唯一可再生、可替代化石能源转化成气态、液态和固态燃料以及其它化工原料或者产品的碳资源。随着化石资源的枯竭和人类对全球性环境问题的关注,生物质能源替代化石能源利用的研究和开发,已成为国内外众多学者研究和关注的热点。本系列讲座主要讲述以生物质资源为主要原料,通过不同途径转化为洁净的、高品位的气体、液体或固体燃料。本讲主要综述了生物质高压液化、快速热解液化制备液体燃料油技术现状、工艺及设备,并在总结生物质热解液体燃料油特性的基础上,总结了生物热解液体燃料油的物理法精制技术(包括脱水、添加溶剂和乳化)和化学法精制技术(包括催化加氢、催化裂解、催化酯化、水蒸气重整)的研究现状,并对其精制机理、优缺点进行了分析。随着制备和精制技术的深入研究,生物质热解液体燃料油可望替代汽油、柴油等化石燃料而越来越受到人们的关注。     

紫外法和皮粉法测定塔拉单宁含量的对比研究

分别采用紫外法和皮粉法对5种不同含量的塔拉单宁进行对比研究,并利用SPSS软件对单宁含量测定结果进行显著性检验,结果表明：高纯度塔拉单宁(93%)分别用紫外法和皮粉法测定单宁含量时实验结果并未显著差异(P>0.05),而4种纯度为60%左右塔拉单宁的实验结果均具有显著性差异(P<0.05),皮粉法测得的单宁含量均比用紫外法测得的结果高,差值约为1.5%～2.0%,并由此计算出紫外法测定塔拉单宁含量计算公式中的矫正常数p为1.03。紫外-可见吸收光谱与HPLC分析结果表明：塔拉单宁与五倍子单宁的最大吸收峰均为276 nm,同质量浓度下塔拉单宁的吸收峰强度高于五倍子单宁,塔拉单宁成分出峰时间主要在20～40 min,五倍子单宁主要在30～45 min。     

Catalytic activity of various iron sulphides in coal liquefaction

Iron sulphides with various S-Fe atomic ratios, such as pyrite, iron(III) sulphide, pyrrhotite and troilite, were used as catalysts for coal liquefaction. Catalytic activities were compared on the basis of the temperature of the exothermic peak due to coal hydrogenolysis. Effects of hydrogen sulphide on catalytic activity of iron sulphides were also investigated. It is concluded that:

• 1.1. The catalytic activity of iron sulphides increases with increasing S-Fe ratio;
• 2.2. pyrite, with the highest catalytic activity, is converted to pyrrhotite before the onset of exothermic reactions from coal hydrogenolysis, this evidently being the reason for the high catalytic activity;
• 3.3. the catalytic activity of iron sulphides depends on the coal type;
• 4.4. the high catalytic activity of pyrite may be due to the creation of fresh pyrite surface during the reaction rather than to the presence of high concentrations of hydrogen sulphide.

     

Hydrogenated rosin ester latexes/waterborne polyacrylate blends for pressure‐sensitive adhesives

Diethylene glycol ester of hydrogenated rosin (DGE‐HR) emulsion was prepared via phase inversion method and then blended with waterborne (wb) polyacrylate for pressure‐sensitive adhesives (PSAs). The preparation conditions of DGE‐HR emulsion were studied. DGE‐HR emulsion with an average particle size of about 220 nm was obtained. Furthermore, the thermal, adhesive, and viscoelastic properties and the morphology of DGE‐HR/polyacrylate composite were investigated. Thermal analysis indicated that glass transition temperatures (T_g) of the DGE‐HR/polyacrylate blends became higher as the DGE‐HR content increased and DGE‐HR did not have a significant influence on thermal stability of the blend films. Atomic Force Microscopy (AFM) observation revealed that the DGE‐HR particles added had a good miscibility with acrylic particles. Additionally, for these tackified acrylic PSAs, positive correlations between mechanical performance and viscoelastic response at bonding and debonding frequencies were also found. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 42965.     

PLA/橡实淀粉/二聚脂肪酸聚酰胺复合材料研究

采用熔融挤出法制备了聚乳酸(PLA)/橡实淀粉(AS)/二聚脂肪酸聚酰胺(DAPA)三元复合材料。在保持PLA与AS质量比不变的情况下(60/40),研究了DAPA含量对复合材料的力学性能、疏水性能、热性能和熔体流动速率(MFR)的影响。研究表明,随DAPA添加量的增加,复合材料的疏水性和MFR逐渐提高,而复合材料的拉伸、弯曲强度呈先增大后减小的趋势,且当DAPA质量分数为2%时,复合材料具有最优的力学性能;DAPA的加入增强了PLA与AS的界面相容性,但在一定程度上降低了复合材料的玻璃化转变温度和初始热稳定性。     

松香及其改性产品在助焊剂中的应用现状

综述了国内外用于助焊剂中的多种松香产品及其特性,包括松香、精制松香、氢化松香、歧化松香、聚合松香、松香多元酸、松香酯以及松香胺等,并展望了在助焊剂领域松香改性研究的前景。     

银杏资源加工利用产业发展现状

银杏是我国传统重要的经济林和绿化树种,银杏产业链产值200亿元,是重要的地方农林特色产业.我国的银杏资源占全世界的85％,银杏种植面积约40万hm2,栽培数量达25亿株以上.本文综述了银杏资源量、分布情况及主要利用部位,介绍了银杏主要产品(银杏叶提取物、银杏制剂和白果)及加工技术现状、产品质量控制及其分析检测方法,分析...     

生物基聚氨酯材料的研究进展

聚氨酯作为一种多功能性高分子材料在众多行业中均有广泛应用。利用绿色可再生资源制备聚氨酯材料对聚氨酯的可持续发展具有重要意义。围绕近十年的相关文献,本文重点总结了常见的植物油(蓖麻油、大豆油、桐油和棕榈油等)、木质纤维、松香、天然酚(腰果酚和单宁)和糖类等生物质资源合成生物基多元醇和异氰酸酯的基本方法、研究现状及非异氰酸酯的研究进展,列举这些生物基资源作为原料制备聚氨酯时独特的优点,并在此基础上讨论了生物基聚氨酯材料未来挑战,展望了生物基聚氨酯在不同领域的发展前景。